Publications

論文

Publications (foreign languages)

  1. Nakatsuka R, Yamaguchi Y, Hirohata K, Shimojo S, Murakami M, Rocafort MAV, Tsunaka Y, Fukuhara M, Torisu T, Uchiyama S.

    Multimass Analysis of Adeno-Associated Virus Vectors by Orbitrap-Based Charge Detection Mass Spectrometry
    Anal Chem (2024) Oct 22;96(42):17037-17046.

  2. Yamaguchi Y, Ishii K, Koizumi S, Sakaue H, Maruno T, Fukuhara M, Shibuya R, Tsunaka Y, Matsushita A, Bandoh K, Torisu T, Murata-Kishimoto C, Tomioka A, Mizukado S, Kaji H, Kashiwakura Y, Ohmori T, Kuno A, Uchiyama S.

    Glycosylation of recombinant adeno-associated virus serotype 6.
    Mol Ther Methods Clin Dev(2024) Apr 25;32(2):101256.

  3. Nishiumi H, Hirohata K, Fukuhara M, Matsushita A, Tsunaka Y, Rocafort MAV, Maruno T, Torisu T, Uchiyama S.

    Combined 100 keV Cryo-Electron Microscopy and Image Analysis Methods to Characterize the Wider Adeno-Associated Viral Products
    J Pharm Sci.(2024) Jul;113(7):1804-1815.

  4. Tran THN, Takada R, Krayukhina E, Maruno T, Mii Y, Uchiyama S, Takada S.

    Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion
    Commun Biol(2024) Mar 1;7(1):254.

  5. Onishi T, Nonaka M, Maruno T, Yamaguchi Y, Fukuhara M, Torisu T, Maeda M, Abbatiello S, Haris A, Richardson K, Giles K, Preece S, Yamano-Adachi N, Omasa T, Uchiyama S.

    Enhancement of recombinant adeno-associated virus activity by improved stoichiometry and homogeneity of capsid protein assembly
    Mol Ther Methods Clin Dev(2023) Oct 24;31:101142.

  6. Kurinomaru T, Takeda K, Onaka M, Kuruma Y, Takahata K, Takahashi K, Sakurai H, Sasaki A, Noda N, Honda S, Shibuya R, Ikeda T, Okada R, Torisu T, Uchiyama S.

    Optimization of Flow Imaging Microscopy Setting Using Spherical Beads with Optical Properties Similar to Those of Biopharmaceuticals
    J Pharm Sci(2023) Dec;112(12):3248-3255.

  7. Yui A, Kuroda D, Maruno T, Nakakido M, Nagatoishi S, Uchiyama S, Tsumoto K

    Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene
    Sci Rep(2023) Apr 20;13(1):6493.

  8. Maruno T, Ishii K, Torisu T, Uchiyama S.

    Size Distribution Analysis of the Adeno-Associated Virus Vector by the c(s) Analysis of Band Sedimentation Analytical Ultracentrifugation with Multiwavelength Detection
    J Pharm Sci(2022) Oct 29:S0022-3549(22)00480-4.

  9. Takeda K, Noda M, Maruno T, Uchiyama S.

    Critical Calibration of Mass Photometry for Higher-Mass Samples Such as Adeno-Associated Virus Vectors
    J Pharm Sci(2022) Nov 9:S0022-3549(22)00505-6.

  10. Oki H, Kawahara K, Iimori M, Imoto Y, Nishiumi H, Maruno T, Uchiyama S, Muroga Y, Yoshida A, Yoshida T, Ohkubo T, Matsuda S, Iida T, Nakamura S.

    Structural basis for the toxin-coregulated pilus-dependent secretion of Vibrio cholerae colonization factor
    Sci Adv(2022) Oct 14;8(41):eabo3013.

  11. Nishiumi H, Deiringer N, Krause N, Yoneda S, Torisu T, Menzen T, Friess W, Uchiyama S.

    Utility of Three Flow Imaging Microscopy Instruments for Image Analysis in Evaluating four Types of Subvisible Particle in Biopharmaceuticals
    J Pharm Sci(2022) Nov;111(11):3017-3028.

  12. Shibata H, Terabe M, Shibano Y, Saitoh S, Takasugi T, Hayashi Y, Okabe S, Yamaguchi Y, Yasukawa H, Suetomo H, Miyanabe K, Ohbayashi N, Akimaru M, Saito S, Ito D, Nakano A, Kojima S, Miyahara Y, Sasaki K, Maruno T, Noda M, Kiyoshi M, Harazono A, Torisu T, Uchiyama S, Ishii-Watabe A.

    A Collaborative Study on the Classification of Silicone Oil Droplets and Protein Particles Using Flow Imaging Method.
    J Pharm Sci(2022) Oct;111(10):2745-2757.

  13. Puri S, Chen SN, Chiu YH, Draczkowski P, Ko KT, Yang TJ, Wang YS, Uchiyama S, Hsu SD.

    Impacts of Cancer-associated Mutations on the Structure-Activity Relationship of BAP1
    J Mol Biol(2022) May 15;434(9):167553.

  14. Nakagawa Y, Shen HC, Komi Y, Sugiyama S, Kurinomaru T, Tomabechi Y, Krayukhina E, Okamoto K, Yokoyama T, Shirouzu M, Uchiyama S, Inaba M, Niwa T, Sako Y, Taguchi H, Tanaka M.

    Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system.
    Nat Chem Biol(2022) Mar;18(3):321-331.

  15. Abe K, Kabe Y, Uchiyama S, Iwasaki YW, Ishizu H, Uwamino Y, Takenouchi T, Uno S, Ishii M, Maruno T, Noda M, Murata M, Hasegawa N, Saya H, Kitagawa Y, Fukunaga K, Amagai M, Siomi H, Suematsu M, Kosaki K; Keio Donner Project.

    Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19.
    Sci Rep(2022) Jan 25;12(1):1299.

  16. Fujiwara S, Ueda T, Ishii N, Abe Y, Hayashihara-Kakuhou K, Takeda K, Kurinomaru T, Fukuhara A, Uchiyama S, Carpenter JF.

    Chemical-gas Sterilization of External Surface of Polymer-based Prefilled Syringes and Its Effect on Stability of Model Therapeutic Protein.
    J Pharm Sci(2022) Jan;111(1):41-50.

  17. Fukuhara A, Anzai Y, Osawa K, Umeda M, Minemura H, Shiramizu N, Yokoyama M, Uchiyama S.

    Plate Reader-Based Analytical Method for the Size Distribution of Submicron-Sized Protein Aggregates Using Three-Dimensional Homodyne Light Detection.
    J Pharm Sci(2021) Dec;110(12):3803-3810.

  18. Yoneda S, Maruno T, Mori A, Hioki A, Nishiumi H, Okada R, Murakami M, Zekun W, Fukuhara A, Itagaki N, Harauchi Y, Adachi S, Okuyama K, Sawaguchi T, Torisu T, Uchiyama S.

    Influence of Protein Adsorption on Aggregation in Prefilled Syringes.
    J Pharm Sci(2021) Nov;110(11):3568-3579.

  19. Kabe Y, Koike I, Yamamoto T, Hirai M, Kanai A, Furuhata R, Tsugawa H, Harada E, Sugase K, Hanadate K, Yoshikawa N, Hayashi H, Noda M, Uchiyama S, Yamazaki H, Tanaka H, Kobayashi T, Handa H, Suematsu M.

    Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1.
    Cancers (Basel)(2021) Jun 29;13(13):3265.

  20. Gambe-Gilbuena A, Shibano Y, Krayukhina E, Torisu T, Uchiyama S.

    Automatic Identification of the Stress Sources of Protein Aggregates Using Flow Imaging Microscopy Images.
    J Pharm Sci(2020) Jan;109(1):614-623.

  21. Oyama H, Koga H, Tadokoro T, Maenaka K, Shiota A, Yokoyama M, Noda M, Torisu T, Uchiyama S.

    Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody.
    J Pharm Sci(2020) Jan;109(1):308-315.

  22. Krayukhina E, Fukuhara A, Uchiyama S.

    Assessment of the Injection Performance of a Tapered Needle for Use in Prefilled Biopharmaceutical Products.
    J Pharm Sci(2020) Jan;109(1):515-523.

  23. Noda M, Ishii K, Yamauchi M, Oyama H, Tadokoro T, Maenaka K, Torisu T, Uchiyama S.

    Identification of IgG1 Aggregation Initiation Region by Hydrogen Deuterium Mass Spectrometry.
    J Pharm Sci(2019) Jul;108(7):2323-2333.

  24. Krayukhina E, Yokoyama M, Hayashihara KK, Maruno T, Noda M, Watanabe H, Uchihashi T, Uchiyama S.

    An Assessment of the Ability of Submicron- and Micron-Size Silicone Oil Droplets in Dropped Prefillable Syringes to Invoke Early- and Late-Stage Immune Responses.
    J Pharm Sci(2019) Jul;108(7):2278-2287.

  25. Harazono A, Shibata H, Kiyoshi M, Muto T, Fukuda J, Torisu T, Saitoh S, Nishimura H, Uchiyama S, Ishii-Watabe A.

    Interlaboratory comparison about feasibility of insoluble particulate matter test for injections with reduced test volume in light obscuration method.
    Biologicals(2019) Jan;57:46-49.

  26. Yoneda S, Niederleitner B, Wiggenhorn M, Koga H, Totoki S, Krayukhina E, Friess W, Uchiyama S.

    Quantitative laser diffraction (qLD) for a quantification of protein aggregates – comparison with resonant mass measurement, nano-particle tracking, flow imaging and light obscuration.
    J Pharm Sci(2019) Jan;108(1):755-762.

  27. Takada R, Mii Y, Krayukhina E, Maruyama Y, Mio K, Sasaki Y, Shinkawa T, Pack CG, Sako C, Uchiyama S, Takada S.

    Assembly of protein complexes restricts diffusion of Wnt3a proteins.
    Commun Biol(2018) Oct 10;1:165.

  28. Kiyoshi M, Shibata H, Harazono A, Torisu T, Maruno T, Akimaru M, Asano Y, Hirokawa M, Ikemoto K, Itakura Y, Iwura T, Kikitsu A, Kumagai T, Mori N, Murase H, Nishimura H, Oda A, Ogawa T, Ojima T, Okabe S, Saito S, Saitoh S, Suetomo H, Takegami K, Takeuchi M, Yasukawa H, Uchiyama S, Ishii-Watabe A.

    Collaborative Study For Analysis Of Subvisible Particles Using Flow Imaging And Light Obscuration: Experiences In Japanese Biopharmaceutical Consortium.
    J Pharm Sci(2018) Aug 16. pii: S0022-3549(18)30505-7.

  29. Maruno T, Watanabe H, Yoneda S, Uchihashi T, Adachi S, Arai K, Sawaguchi T, Uchiyama S.

    Sweeping of Adsorbed Therapeutic Protein on Prefillable Syringes Promotes Micron Aggregate Generation.
    J Pharm Sci(2018) Jun;107(6):1521-1529.

  30. Uchiyama S, Noda M, Krayukhina E.

    Sedimentation velocity analytical ultracentrifugation for characterization of therapeutic antibodies.
    Biophys Rev(2018) Apr;10(2):259-269.

  31. Yanaka S, Yamazaki T, Yogo R, Noda M, Uchiyama S, Yagi H, Kato K.

    NMR Detection of Semi-Specific Antibody Interactions in Serum Environments.
    Molecules(2017) Sep 27;22(10).

  32. Krayukhina E, Noda M, Ishii K, Maruno T, Wakabayashi H, Tada M, Suzuki T, Ishii-Watabe A, Kato M, Uchiyama S.

    Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments.
    MAbs(2017) May/Jun;9(4):664-679.

  33. Oda M, Tanabe Y, Noda M, Inaba S, Krayukhina E, Fukada H, Uchiyama S.

    Structural and binding properties of laminarin revealed by analytical ultracentrifugation and calorimetric analyses.
    Carbohydr Res(2016) Aug 5;431:33-8.

  34. Toma-Fukai S, Kim JD, Park KE, Kuwabara N, Shimizu N, Krayukhina E, Uchiyama S, Fukamizu A, Shimizu T.

    Novel helical assembly in arginine methyltransferase 8.
    J Mol Biol(2016) Mar 27;428(6):1197-1208.

  35. Kita S, Matsubara H, Kasai Y, Tamaoki T, Okabe Y, Fukuhara H, Kamishikiryo J, Krayukhina E, Uchiyama S, Ose T, Kuroki K, Maenaka K.

    Crystal structure of extracellular domain of human lectin-like transcript 1 (LLT1), the ligand for natural killer receptor-P1A.
    Eur J Immunol(2015) Jun;45(6):1605-13.

  36. Ohto U, Shibata T, Tanji H, Ishida H, Krayukhina E, Uchiyama S, Miyake K, Shimizu T.

    Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.
    Nature(2015) Apr 30;520(7549):702-5.

  37. Han W, Yamauchi M, Hasegawa U, Noda M, Fukui K, van der Vlies AJ, Uchiyama S, Uyama H.

    Pepsin immobilization on an aldehyde-modified polymethacrylate monolith and its application for protein analysis.
    J Biosci Bioeng(2015) May;119(5):505-10.

  38. Krayukhina E, Tsumoto K, Uchiyama S, Fukui K.

    Effects of syringe material and silicone oil lubrication on the stability of pharmaceutical proteins.
    J Pharm Sci(2015) Feb;104(2):527-35.

  1. クラユヒナ　エレナ，米田　早紀，古賀　博己，丸野　孝浩，内山　進

    バイオ医薬品の分析のコツ 品質評価のための基礎と応用（第10回）タンパク質の凝集と凝集体評価
    ファームテックジャパン33、5月号 (2018)

  2. 内山　進

    バイオ医薬の分析のコツ品質評価のための基礎と応用（第6回） タンパク質溶液の性質
    ファームテックジャパン33、1月号 (2018)

  3. 林原　加代子，宮原　佑弥，丸野　孝浩，野田　勝紀，内山　進

    バイオ医薬の分析のコツ品質評価のための基礎と応用（第3回） タンパク質の構造を知る
    ファームテックジャパン33、10月号 (2017)

  4. 石井　健太郎、内山　進

    タンパク質のネイティブ質量分析—動的なタンパク質複合体形成の解明に向けて—
    ぶんせき10、472-475 (2017)

  5. 内山　進

    蛋白質溶液製剤の安定性評価と最適化
    ケミカルエンジニヤリング8月号、1-6 (2017)

  6. 内山　進

    バイオ医薬品の物理化学分析の重要性と必要性より安全な価値の高いタンパク質製剤の開発にむけて
    ファームテックジャパン33, 89-94 (2017)

  7. Uchiyama S

    Biophysical Characterization of Biopharmaceuticals, Including Antibody Drugs
    Yakugaku Zasshi.136, 443-8 (2016)

  8. 野田　勝紀、クラユヒナ　エレナ、橫山　雅美、内山　進

    超遠心沈降速度法によるナノ粒子の粒子径測定
    粉体技術Vol.7, No.7 (2015)

  9. 内山　進、石井　健太郎、野田　勝紀

    質量分析による蛋白質の高次構造解析
    生物物理321(2015)

  10. 内山　進、エレナ　クラユヒナ、野田　勝紀

    抗体医薬品の溶液物性
    薬剤学74 (1), 12-18　(2014)

  11. 内山　進、野田　勝紀、福井　希一

    超遠心分析および非変性質量分析法によるタンパク質間相互作用解析
    生物工学会第89巻　第7号　371-374　(2011)
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