We are pleased to share our recent publication in Scientific Reports:
“Inducible rAAV producer cell lines yield vectors equivalent to transient transfection: a physicochemical and biological comparison”

https://pubmed.ncbi.nlm.nih.gov/42362583/

In this collaborative study led by FUJIFILM Corporation, with contributions from U-Medico Inc., The University of Osaka, and Gunma University, we evaluated recombinant adeno-associated virus (rAAV) vectors produced using inducible producer cell lines and compared them with vectors produced by conventional transient transfection.
The study demonstrated that producer cell line-derived rAAV particles showed comparable physicochemical properties, including capsid protein composition, genome packaging length, and sedimentation coefficient, as well as comparable biological activity in vitro and in vivo.
These findings support the potential of inducible producer cell line technology as a promising platform for scalable rAAV manufacturing.
We are honored to have contributed to the physicochemical characterization of rAAV vectors in this important study.